Drug Interactions with Chewable Sildenafil Medications

Store at room temperature away from light and moisture.

Combining Nitrate Pre-Workout and BlueChew: Safety Insights

In particular, make sure that you discuss if you are using any of the following before taking sildenafil. Tell your healthcare provider about all medicines that you take or have recently taken. This may not be a complete list of medicines that can interact with sildenafil. If you or someone else has used too much sildenafil, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222. For this use, sildenafil is used only when needed.

Altitude sickness

Take it as your healthcare provider recommends, which is usually between 30 minutes to four hours before planned sexual activity. Do not take double or extra doses. For this use, take sildenafil as your healthcare provider recommends, which is usually three times a day. If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose.

What should I know about sildenafil before taking it?

Ask your healthcare provider if you are unsure what to do after a missed dose. This survey is being conducted by the WebMD marketing sciences department. Sildenafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, sildenafil works by increasing blood flow to the penis to help a person get and keep an erection. This drug does not protect against sexually transmitted diseases (such as HIV, hepatitis B, gonorrhea, syphilis). Keep all medications away from children and pets.

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Do not flush medications down the toilet or pour them into a drain unless instructed to do so.

• Sildenafil can cause temporary vision changes in some users.
• Chewing sildenafil isn't recommended by healthcare professionals.
• Sildenafil’s effects typically last around 4-6 hours.
• Do not take sildenafil more than once in a 24-hour period.
• Always read the leaflet included with sildenafil medication.
• Be aware that chewing sildenafil may impact drug stability.
• Use sildenafil only as prescribed by a healthcare professional.
• Be mindful of potential interactions with alcohol or other drugs.
• Monitor for adverse reactions after taking sildenafil.

Properly discard this product when it is expired or no longer needed.

Society and culture

Using an effective barrier method (latex or polyurethane condom/dental dams) during sexual activity will help to decrease your risk of infection. This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. Sildenafil is also available in other brands and strengths for high blood pressure in the lungs (pulmonary hypertension). Read the Patient Information Leaflet if available from your pharmacist before you start taking sildenafil and each time you get a refill.

Keep in mind

If you have any questions, ask your doctor or pharmacist. To treat erectile dysfunction-ED, take this drug by mouth as directed by your doctor, usually as needed. Take sildenafil at least 30 minutes, but no more than 4 hours, before sexual activity (1 hour before works best). This medication may take longer to start working if you take it with a high-fat meal. Do not take more than once daily as needed.

Key takeaways

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Tell your doctor if your condition does not get better. Dizziness, headache, flushing, or stomach upset may occur. Vision changes such as increased sensitivity to light, blurred vision, or trouble telling blue and green colors apart may also occur. Consult your pharmacist or local waste disposal company.

• Sildenafil works by relaxing blood vessels in the penis.
• Chewing sildenafil might cause a faster onset of action.
• Crushing sildenafil tablets can affect its efficacy and safety.
• Sildenafil is not meant to be chewed, broken, or crushed.
• Use sildenafil as directed by a doctor for optimal results.
• Be aware that chewing sildenafil can increase side effects.
• Sildenafil is available by prescription only in many countries.
• Avoid taking sildenafil with heavy meals or high-fat foods.
• Inform your doctor of any medications you are taking before using sildenafil.

HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product.

Key Questions to Consider

You may report side effects to FDA at 1-800-FDA-1088 or at In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Before taking sildenafil, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Returns and refunds

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (such as heart attack or life-threatening irregular heartbeat in the past 6 months, chest pain/angina, heart failure) penis conditions (such as angulation, fibrosis/scarring, Peyronie's disease) conditions that may increase the risk of priapism (such as sickle cell anemia, leukemia, multiple myeloma) eye problems (such as retinitis pigmentosa, sudden decreased vision, NAION) This drug may make you dizzy or cause vision problems. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Talk to your doctor if you are using marijuana (cannabis). Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

How is sildenafil supplied (dosage forms)?

During pregnancy, sildenafil should be used only when clearly needed. Since high blood pressure in the lungs is a serious condition that can harm both a pregnant woman and her unborn baby, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, discuss with your doctor right away the benefits and risks of using this medication during pregnancy. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. This information does not assure that this product is safe, effective, or appropriate for you.

Route of administration

Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug are: Sildenafil can cause a serious drop in your blood pressure when used with nitrates. A serious drop in blood pressure can lead to dizziness, fainting, and rarely heart attack or stroke. Do not use sildenafil with any of the following: certain drugs used to treat chest pain/angina (nitrates such as nitroglycerin, isosorbide) recreational drugs called "poppers" containing amyl or butyl nitrite If you are also taking an alpha blocker medication (such as doxazosin, tamsulosin) to treat an enlarged prostate/BPH or high blood pressure, your blood pressure may get too low which can lead to dizziness or fainting. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

Important things to remember

If any of these effects last or get worse, tell your doctor or pharmacist promptly. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Sexual activity may put extra strain on your heart, especially if you have heart problems.

Warnings for other groups

If you have heart problems and experience any of these serious side effects while having sex, stop and get medical help right away: Rarely, sudden decreased vision, or even permanent blindness, may occur in one or both eyes (NAION). If this serious problem occurs, stop taking sildenafil and get medical help right away. You have a slightly greater chance of developing NAION if you have heart disease, diabetes, high cholesterol, certain other eye problems ("crowded disk"), high blood pressure, if you are over 50, or if you smoke. Rarely, a sudden decrease or loss of hearing, sometimes with ringing in the ears and dizziness, may occur. Stop taking sildenafil and get sildenafil 20 mg tablets medical help right away if these effects occur.

Recreational use

Rarely, males may have a painful or prolonged erection lasting 4 or more hours. If this occurs, stop using this drug and get medical help right away, or permanent problems could occur. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: itching/swelling (especially of the face/tongue/throat) This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Selected from NATIONAL DRUG DATA FILE (NDDF) data included with permission and copyrighted by First Databank, Inc., 2019. This copyrighted material has been downloaded from a licensed data provider.

• Sildenafil is a prescription medication approved for ED treatment.
• Chewing sildenafil may cause a rapid release of the drug.
• Using sildenafil without medical advice can be risky.
• Sildenafil can interact with drugs used for prostate issues.
• Stop using sildenafil if you experience chest pain or dizziness.
• Be cautious with non-standard administration methods.
• Sildenafil is generally well-tolerated when used as directed.
• Regular medical check-ups are recommended during sildenafil therapy.
• Educate yourself about possible side effects before use.

The above information is intended to supplement, not substitute for, the expertise and judgment of your health care professional.

Types of PDE5 inhibitors

Your doctor may start treatment with a lower dose of sildenafil to minimize your risk of low blood pressure. Other medications can affect the removal of sildenafil from your body, which may affect how sildenafil works. Examples include azole antifungals (such as itraconazole, ketoconazole), macrolide antibiotics (such as clarithromycin, erythromycin), mifepristone, rifampin, ritonavir, among others. Do not take this medication with any other product that contains sildenafil or other similar medications for erectile dysfunction-ED or pulmonary hypertension (such as tadalafil, vardenafil). If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. You should consult your health care professional before taking any drug, changing your diet, or commencing or discontinuing any course of treatment.

How long does SIL last?

Otherwise, call a poison control center right away. US residents can call 1-800-222-1222. Canada residents can call 1-844-764-7669. Symptoms of overdose may include: severe dizziness, fainting, painful/prolonged erection. Do not share this medication with others. With our reliable online store, which offers safe transactions and efficient erectile dysfunction treatments, you may shop with confidence.

Parameter	Data	Explanation
Absorption Time	15-30 min	Faster than standard tablets
Peak Plasma Levels	1 hour	When maximum effect occurs
Half-life	4 hours	Time for plasma concentration to reduce by half
Metabolism	Liver (CYP3A4 enzyme)	Main pathway for breakdown